New norditerpenoids with trypanocidal activity from Vitex trifolia.
نویسندگان
چکیده
Trypanocidal constituents of the fruits of Vitex trifolia were investigated. Activity-guided isolation of the acetone extract resulted in the isolation of two new norditerpene aldehydes, 1 and 2, together with five known diterpenes: vitexifolin E (3), vitexifolin F (4), vitexilactone (5), 6-acetoxy-9-hydroxy-13(14)-labden-16,15-olide (6), and previtexilactone (7). In vitro minimum lethal concentrations of the isolated compounds against epimastigotes of Trypanosoma cruzi were 11 microM (1), 36 microM (2), 34 microM (3), 34 microM (4), 66 microM (5), 66 microM (6), and >265 microM (7).
منابع مشابه
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ورودعنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 52 12 شماره
صفحات -
تاریخ انتشار 2004